Medications Known to Cause TEN
Drugs known to cause TEN include:
Antibiotics such as sulfonamides, penicillins, macrolides, and quinolones Anticonvulsant (antiseizure) drugs Non-steroidal anti-inflammatory drugs (NSAIDs) Allopurinol Tumor necrosis factor (TNF)-alpha drugs such as Remicade (infliximab), Enbrel (etanercept), and Humira (adalimumab)
Cases that are drug-induced usually occur within one to three weeks of starting the treatment. It is rare for drug reactions to happen after eight weeks. Approximately one-third of the cases are caused by unknown factors.
Symptoms
Toxic epidermal necrolysis generally begins with flu-like symptoms such as fever, cough, sore throat, runny nose, and a general feeling of discomfort for two to three days. These symptoms may then progress to include:
Small red spots that develop into large patches of red skin that cover 30 percent or more of the body Extensive blistering and peeling of the skin Exposed moist, red, painful areas where the skin has peeled off Cracked, bleeding lips that form crusts Sore eyes (conjunctivitis) Extreme pain
These symptoms usually last eight to 12 days. Due to the severity of these symptoms, complications may develop, such as pneumonia; sloughing of mucous membranes in the mouth, throat and digestive tract; skin infections; kidney failure, blood poisoning (sepsis), and shock. Without proper treatment, many of these side effects can become fatal.
Diagnosis
TEN is typically diagnosed based on the patient’s symptoms as well as a physical examination of the skin. Other skin disorders, such as staphylococcal scalded skin syndrome, may have similar symptoms. Often, a skin sample (biopsy) will be taken to confirm TEN and rule out any other disorders.
Medical Treatment
Toxic epidermal necrolysis can cause life-threatening complications. If you think you may have TEN, seek medical treatment. TEN is considered a medical emergency and requires prompt treatment. The earlier the condition is treated, the better the prognosis is. Treatment options may include:
Stopping any medications which can cause TENIntravenous (IV) fluids and electrolytesRemoving of dead skin tissue (debridement)Protective bandagesAntibiotics to prevent or treat infectionsPain medicineTreating complications such as pneumonia or kidney failureUsing a feeding tube to deliver nutrients
Treatment may also include IV immunoglobulin, cyclosporine, plasmapheresis, or hyperbaric oxygen. Studies have shown that those who are transferred to the burn or intensive care unit early have lowered rates of infection as well as a decreased mortality rate and length of hospitalization. Any medication that can cause TEN should be stopped immediately. One study showed that TEN-related deaths could be reduced by 5 to 25 percent if the offending medication was stopped as soon as blistering starts.
